Plantago depressa Willd. (Plantaginaceae) belonging to the section Mesembrynia and subgenus Plantago has been used as a traditional medicine. Here, we presented the complete chloroplast genome of P. depressa which is 164,617 bp long and has four subregions: 82,933 bp of large single copy (LSC) and 4,908 bp of small single copy (SSC) regions are separated by 38,388 bp of inverted repeat (IR) regions including 139 genes (93 protein-coding genes, eight rRNAs, and 38 tRNAs). The overall GC contents of the chloroplast genome were 38.0\% and in the LSC, SSC, and IR regions were 36.6\%, 30.6\%, and 39.9\%, respectively. Phylogenetic tree constructed with concatenated 79 protein-coding genes sequences of the chloroplast genomes in Plantaginaceae from APG group presents the phylogenetic position of P. depressa.